Marc-André Bédard

Professeur

Photo de Marc-André Bédard
Téléphone : (514) 987-3000 poste 0220
Local : SU-1205
Langues : Français, Anglais
Liens d'intérêt
Informations générales

Unités de recherche

Projets de recherche en cours

  • Imagerie cérébrale (PET scan) des systèmes cholinergiques dans les maladies neurodégénératives (Alzheimer, Parkinson ...)

Partenaires (organismes, entreprises)

  • Financement: Sociétés pharmaceutiques, IRSC et FRQS.

Affiliations externes principales

Enseignement
Distinctions

Directions de thèses et mémoires

Thèses de doctorat
Mémoires
Travaux dirigés
  • Semkovska, Maria. (2003). La neuropsychologie et la psychopharmacologie: exemples de fécondation réciproque. (Travail dirigé). Université du Québec à Montréal.
  • Lemay, Simon. (2002). Induction of a transient dysexecutive syndrome in Parkinson's disease using a subclinical dose of scopolamine. (Travail dirigé). Université du Québec à Montréal.
  • Duchesne, Nicole. (2000). ACUTE AND LONG-TERM ADMINISTRATION OF ANTICHOLINERGICS IN PARKINSON'S DISEASE: SPECIFIC EFFECTS ON THE SUBCORTICO-FRONTAL SYNDROME. (Travail dirigé). Université du Québec à Montréal.
Rapports d'activités et projets d'intervention
  • Scherer, Hélène. (1999). EFFETS DIFFERENTIELS DES NEUROLEPTIQUES A FORTE AFFINITE D2 ET D4 SUR L'APPRENTISSAGE PROCEDURAL DANS LA SCHIZOPHRENIE. (Rapport d'activités et projet d'intervention). Université du Québec à Montréal.

Publications

Articles scientifiques
  • Bédard, M.-A., Aghourian, M., Legault-Denis, C., Postuma, R.B., Soucy, J.-P., Gagnon, J.-F., Pelletier, A. et Montplaisir, J. (2019). Brain cholinergic alterations in idiopathic REM sleep behaviour disorder: a PET imaging study with 18 F-FEOBV. Sleep Medicine, 58, 35–41. http://dx.doi.org/10.1016/j.sleep.2018.12.020.
  • Schmitz, T.W., Mur, M., Aghourian, M., Bédard, M.-A. et Spreng, R.N. (2018). Longitudinal Alzheimer’s degeneration reflects the spatial topography of cholinergic basal forebrain projections. Cell Reports, 24(1), 38–46. http://dx.doi.org/10.1016/j.celrep.2018.06.001.
  • Dulude, G., O'Connor, K., Audet, J.S. et Bédard, M.-A. (2017). Over facilitation of unadapted cognitive processes in obsessive compulsive disorder as assessed with the computerized mirror pointing task. Journal of Psychiatric Research, 89, 73–80. http://dx.doi.org/10.1016/j.jpsychires.2017.01.014.
  • Aghourian, M., Legault-Denis, C., Soucy, J.P., Rosa-Neto, P., Gauthier, S., Kostikov, A., Gravel, P. et Bédard, M.-A. (2017). Quantification of brain cholinergic denervation in Alzheimer's disease using PET imaging with [18 F]-FEOBV. Molecular Psychiatry, 22, 1531–1538. http://dx.doi.org/10.1038/mp.2017.183.
  • Cyr, M., Parent, M.J., Mechawar, N., Rosa-Neto, P., Soucy, J.-P., Clark, S.D., Aghourian, M. et Bédard, M.-A. (2015). Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [¹⁸F] fluoroethoxybenzovesamicol. Behavioural Brain Research, 278, 107–114. http://dx.doi.org/10.1016/j.bbr.2014.09.021.
  • Cyr, M., Parent, M.J., Mechawar, N., Rosa-Neto, P., Soucy, J.-P., Aliaga, A., Kostikov, A., Maclaren, D.A., Clark, S.D. et Bédard, M.-A. (2014). PET imaging with [¹⁸F]fluoroethoxybenzovesamicol ([¹⁸F]FEOBV) following selective lesion of cholinergic pedunculopontine tegmental neurons in rat. Nuclear Medicine and Biology, 41(1), 96–101. http://dx.doi.org/10.1016/j.nucmedbio.2013.10.004.
  • Parent, M.J., Bédard, M.-A., Aliaga, A., Minuzzi, L., Mechawar, N., Soucy, J.-P., Schirrmacher, E., Kostikov, A., Gauthier, S.G. et Rosa-Neto, P. (2013). Cholinergic Depletion in Alzheimer's Disease Shown by [18F]FEOBV Autoradiography. International Journal of Molecular Imaging, 2013, Article ID 205045. http://dx.doi.org/10.1155/2013/205045.
  • Parent, M.J., Cyr, M., Aliaga, A., Kostikov, A., Schirrmacher, E., Soucy, J.-P., Mechawar, N., Rosa-Neto, P. et Bédard, M.-A. (2013). Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry. EJNMMI Research, 3, article 70. http://dx.doi.org/10.1186/2191-219X-3-70.
  • Parent, M., Bédard, M.-A., Aliaga, A., Soucy, J.-P., Landry St-Pierre, E., Cyr, M., Kostikov, A., Schirrmacher, E., Massarweh, G. et Rosa-Neto, P. (2012). PET imaging of cholinergic deficits in rats using [18F]fluoroethoxybenzovesamicol ([18F]FEOBV). NeuroImage, 62(1), 555–561. http://dx.doi.org/10.1016/j.neuroimage.2012.04.032.
  • Tremblay, P.L., Bédard, M.-A., Langlois, D., Blanchet, P.J., Lemay, M. et Parent, M. (2010). Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson’s disease. Experimental Brain Research, 205, 375–385. http://dx.doi.org/10.1007/s00221-010-2372-6.
  • Tremblay, P.-L., Bédard, M.-A., Levesque, M., Chebli, M., Parent, M., Courtemanche, R. et Blanchet, P.J. (2009). Motor sequence learning in primate: Role of the D2 receptor in movement chunking during consolidation. Behavioural Brain Research, 198(1), 231–239. http://dx.doi.org/10.1016/j.bbr.2008.11.002.
  • Paquet, F., Bédard, M.-A., Levesque, M., Tremblay, P.-L., Lemay, M., Blanchet, P.J., Scherzer, P., Chouinard, S. et Filion, J. (2008). Sensorimotor adaptation in Parkinson’s disease: evidence for a dopamine dependent remapping disturbance. Experimental Brain Research, 185, 227–236. http://dx.doi.org/10.1007/s00221-007-1147-1.
  • Levesque, M., Bédard, M.-A., Courtemanche, R., Tremblay, P.-L., Scherzer, P. et Blanchet, P.J. (2007). Raclopride-induced motor consolidation impairment in primates: role of the dopamine type-2 receptor in movement chunking into integrated sequences. Experimental Brain Research, 182, 499–508. http://dx.doi.org/10.1007/s00221-007-1010-4.
  • Rockwood, K., Black, S., Bédard, M.-A., Tran, T. et Lussier, I. (2007). Specific symptomatic changes following donepezil treatment of Alzheimer's disease: a multi-centre, primary care, open-label study. International Journal of Geriatric Psychiatry, 22(4), 312–319. http://dx.doi.org/10.1002/gps.1675.
  • Boulet, C., Lemay, M., Bédard, M.-A., Chouinard, M.-J., Chouinard, S. et Richer, F. (2005). Early Huntington’s disease affects movements in transformed sensorimotor mappings. Brain and Cognition, 57(3), 236–243. http://dx.doi.org/10.1016/j.bandc.2004.09.001.
  • Semkovska, M., Bédard, M.-A, Godbout, L., Limoge, F. et Stip, E. (2004). Assessment of executive dysfunction during activities of daily living in schizophrenia. Schizophrenia Research, 69(2-3), 289–300. http://dx.doi.org/10.1016/j.schres.2003.07.005.
  • Gagnon, J.-F., Fantini, M.-L., Bédard, M.-A., Petit, D., Carrier, J., Rompré, S., Décary, A., Panisset, M. et Montplaisir, J. (2004). Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia. Neurology, 62(3). http://dx.doi.org/10.1212/01.wnl.0000106460.34682.e9.
  • Paquet, F., Soucy, J.-P., Stip, E., Lévesque, M., Elie, A. et Bédard, M.-A. (2004). Comparison between olanzapine and haloperidol on procedural learning and the relationship with striatal D2 receptor occupancy in schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences, 16(1), 47–56. http://dx.doi.org/10.1176/jnp.16.1.47.
  • Lemay, S., Chouinard, S., Blanchet, P., Masson, H., Soland, V., Beuter, A. et Bédard, M.-A. (2004). Lack of efficacy of a nicotine transdermal treatment on motor and cognitive deficits in Parkinson's disease. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 28(1), 31–39. http://dx.doi.org/10.1016/S0278-5846(03)00172-6.
  • Lemay, S., Bédard, M.-A., Rouleau, I. et Tremblay, P.-L. (2004). Practice effect and test-retest reliability of attentional and executive tests in middle-aged to elderly subjects. The Clinical Neuropsychologist, 18(2), 284–302. http://dx.doi.org/10.1080/13854040490501718.
  • Scherer, H., Bédard, M.-A., Stip, E., Paquet, F., Richer, F., Bériault, M., Rodriguez, J.-P. et Motard, J.-P. (2004). Procedural learning in schizophrenia can reflect the pharmacologic properties of the antipsychotic treatments. Cognitive and Behavioral Neurology, 17(1), 32–40. http://dx.doi.org/10.1097/00146965-200403000-00004.
  • Quevillon, F. et Bédard, M.-A. (2003). Benzodiazépines : conséquences sur le fonctionnement mnésique des personnes âgées [Benzodiazepines: Consequences on memory in the elderly]. Santé mentale au Québec, 28(2), 23–41. http://dx.doi.org/10.7202/008615ar.
  • Schérer, H., Stip, E., Paquet, F. et Bédard, M.-A. (2003). Mild procedural learning disturbances in neuroleptic-naive patients with schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences, 15(1), 58–63. http://dx.doi.org/10.1176/jnp.15.1.58.
  • Lemay, S., Blanchet, P., Chouinard, S., Masson, H., Soland, V. et Bédard, M.-A. (2003). Poor tolerability of a transdermal nicotine treatment in Parkinson's disease. Clinical Neuropharmacology, 26(5), 227–229. http://dx.doi.org/10.1097/00002826-200309000-00004.
  • Semkovska, M., Stip, E., Godbout, L., Paquet, F. et Bédard, M.-A. (2002). Behavioral disorganization in schizophrenia during a daily activity: the kitchen behavioral scoring scale. Brain and Cognition, 48(2-3), 546–553. http://dx.doi.org/10.1006/brcg.2001.1415.
  • Duchesne, N., Soucy, J.-P., Masson, H., Chouinard, S. et Bédard, M.-A. (2002). Cognitive deficits and striatal dopaminergic denervation in Parkinson's disease: a single photon emission computed tomography study using 123iodine-β-CIT in patients on and off levodopa. Clinical Neuropharmacology, 25(4), 216–224. http://dx.doi.org/10.1097/00002826-200207000-00005.
  • Gagnon, J.-F., Montplaisir, J. et Bédard, M.-A. (2002). Les troubles du sommeil paradoxal dans la maladie de Parkinson [Rapid-eye-movement sleep disorders in Parkinson's disease]. Revue Neurologique, 158(2), 135–269.
  • Gagnon, J.-F., Bédard, M.-A., Fantini, M.-L., Petit, D., Panisset, M., Rompré, S., Carrier, J. et Montplaisir, J. (2002). REM sleep behavior disorder and REM sleep without atonia in Parkinson’s disease. Neurology, 59(4), 585–589. http://dx.doi.org/10.1212/wnl.59.4.585.
  • Semkovska, M., Bédard, M.-A. et Stip, E. (2001). Hypofrontalité et symptômes négatifs dans la schizophrénie : synthèse des acquis anatomiques et neuropsychologiques et perspectives écologiques [Hypofrontality and negative symptoms in schizophrenia: synthesis of anatomic and neuropsychological knowledge and ecological perspectives]. L'Encéphale, 27(5), 405–415.
    Obtenir ce livre à l'UQAMObtenir "Hypofrontalité et symptômes négatifs dans la schizophrénie : synthèse des acquis anatomiques et neuropsychologiques et perspectives écologiques [Hypofrontality and negative symptoms in schizophrenia: synthesis of anatomic and neuropsychological knowledge and ecological perspectives]" aux bibliothèques de l'UQAM
  • Rouleau, I., Imbault, H., Laframboise, M. et Bédard, M.-A. (2001). Pattern of intrusions in verbal recall: comparison of Alzheimer's disease, Parkinson's disease, and frontal lobe dementia. Brain and Cognition, 46(1-2), 244–249. http://dx.doi.org/10.1016/s0278-2626(01)80076-2.
  • Bédard, M.-A., Schérer, H., Stip, E., Cohen, H., Rodriguez, J.-P., et Richer, F. (2000). Procedural learning in schizophrenia: further consideration on the deleterious effect of neuroleptics. Brain and Cognition, 43(1-3), 31–39. http://dx.doi.org/10.1006/brcg.1999.1133.
  • Bédard, M.-A., Pillon, B., Dubois, B., Duchesne, N., Masson, H. et Agid, Y. (1999). Acute and Long-Term Administration of Anticholinergics in Parkinson's Disease: Specific Effects on the Subcortico-Frontal Syndrome. Brain and Cognition, 40(2), 289–313. http://dx.doi.org/10.1006/brcg.1999.1083.
  • Bédard, M.-A., Lemay, S., Gagnon, J.-F., Masson, H. et Paquet, F. (1999). Induction of a transient dysexecutive syndrome in parkinson’s disease using a subclinical dose of scopolamine. Behavioural Neurology, 11, Article ID 316598. http://dx.doi.org/10.1155/1999/316598.
  • Bédard, M.-A., el Massioui, F., Malapani, C., Dubois, B., Pillon, B., Renault, B. et Agid, Y. (1998). Attentional deficits in Parkinson's disease: partial reversibility with naphtoxazine (SDZ NVI-085), a selective noradrenergic alpha 1 agonist. Clinical Neuropharmacology, 21(2), 108–117.
  • Montplaisir, J., Petit, D., Décary, A., Masson, H., Bédard, M.-A., Panisset, M., Rémillard, G. et Gauthier, S. (1997). Sleep and quantitative EEG in patients with progressive supranuclear palsy. Neurology, 49(4), 999–1003. http://dx.doi.org/10.1212/wnl.49.4.999.
  • Bédard, M.-A., Scherer, H., Delorimier, J., Stip, E. et Lalonde, P. (1996). Differential effects of D2- and D4-blocking neuroleptics on the procedural learning of schizophrenic patients. The Canadian Journal of Psychiatry, 41(7), S21–S24. http://dx.doi.org/10.1177/070674379604100704.
  • Bédard, M.-A., Montplaisir, J., Malo, J., Richer, F. et Rouleau, I. (1993). Persistent neuropsychological deficits and vigilance impairment in sleep apnea syndrome after treatment with continuous positive airways pressure (CPAP). Journal of Clinical and Experimental Neuropsychology, 15(2), 330–341. http://dx.doi.org/10.1080/01688639308402567.
  • Bédard, M.-A., el Massioui, F., Pillon, B. et Nandrino, J.L. (1993). Time for reorienting of attention: A premotor hypothesis of the underlying mechanism. Neuropsychologia, 31(3), 241–249. http://dx.doi.org/10.1016/0028-3932(93)90088-h.
  • Montplaisir, J., Bédard, M.-A., Richer, F. et Rouleau, I. (1992). Neurobehavioral manifestations in obstructive sleep apnea syndrome before and after treatment with continuous positive airway pressure. Sleep, 15(suppl. 6), S17–S19. http://dx.doi.org/10.1093/sleep/15.suppl_6.S17.
  • Pison, C., Bédard, M.-A., Malo, J. et Montplaisir, J. (1991). Effets d'une pression négative périthoracique continue sur les désaturations nocturnes des bronchopneumopathies chroniques obstructives [The effect of continuous peri-thoracic negative pressure on nocturnal desaturation of chronic obstructive bronchopneumopathies]. Revue des Maladies Respiratoires, 8(2), 219–224.
  • Bédard, M.-A., Montplaisir, J., Richer, F. et Malo, J. (1991). Nocturnal hypoxemia as a determinant of vigilance impairment in sleep apnea syndrome. CHEST, 100(2), 367–370. http://dx.doi.org/10.1378/chest.100.2.367.
  • Bédard, M.-A., Montplaisir, J., Richer, F., Rouleau, I. et Malo, J. (1991). Obstructive sleep apnea syndrome: pathogenesis of neuropsychological deficits. Journal of Clinical and Experimental Neuropsychology, 13(6), 950–964. http://dx.doi.org/10.1080/01688639108405110.
  • Lapierre, O., Montplaisir, J., Lamarre, M. et Bédard, M.-A. (1990). The effect of gamma-hydroxybutyrate on nocturnal and diurnal sleep of normal subjects: further considerations on REM sleep-triggering mechanisms. Sleep, 13(1), 24–30. http://dx.doi.org/10.1093/sleep/13.1.24.
  • Bédard, M.-A., Montplaisir, J., Godbout, R. et Lapierre, O. (1989). Nocturnal gamma-hydroxybutyrate. Effect on periodic leg movements and sleep organization of narcoleptic patients. Clinical Neuropharmacology, 12(1), 29–36. http://dx.doi.org/10.1097/00002826-198902000-00004.
  • Bédard, M.-A., Montplaisir, J. et Godbout, R. (1987). Effect of L-Dopa on periodic movements in sleep in narcolepsy. European Neurology, 27(1), 35–38. http://dx.doi.org/10.1159/000116126.
  • Montplaisir, J., Godbout, R., Poirier, G. et Bédard M.-A. (1986). Restless legs syndrome and periodic movements in sleep physiopathology and treatment with L-dopa. Clinical Neuropharmacology, 9(5), 456–463. http://dx.doi.org/10.1097/00002826-198610000-00006.

Département de psychologie

Le département de psychologie de l’UQAM est un lieu d’enseignement et de recherche qui regroupe plusieurs professeures et professeurs ayant des expertises diversifiées dans le domaine de la psychologie. Il offre des programmes de formation de 1er, 2e et 3e cycles pouvant mener à des emplois en intervention, en clinique ou en recherche. Certains de nos programmes d’étude donnent accès au titre de psychologue.

Coordonnées

Département de psychologie
100, rue Sherbrooke Ouest
Montréal (Québec) H2X 3P2